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Tissue Fixation

Why is Tissue Fixation Important

In the fields of histology, pathology and cell biology, fixation is a chemical process by which biological tissues are preserved from decay, thereby preventing on-going biochemical reactions.

Tissue Fixation with Formalin

Fixation is the single most important determinant of high quality histological sections. 10% neutral buffered formalin is the most widely used fixative for routine histology. There are many variables when using formalin as a tissue fixative.


  • pH level - Ideal level is between 6-8
  • Ratio of Fixative to tissue Formalin - Standard rate to tissue volume is 10:1
  • Stability - Correct buffers added to the formalin insure that the formalin remains stable.

Incomplete or poor tissue fixation can lead to poor and unsatisfactory results.

Serosep - Taking Fixation of Tissue Samples to a Higher Level

Serosep began manufacturing biopsy fixatives in 1999. Today Serosep fixatives are sold to over 30 countries worldwide.


With more than 15 years’ experience in the manufacture of biopsy fixatives Serosep can today offer a range of fixatives that include:


  • Formalin
  • Denatured Alcohols
  • Bouins fixative
  • Customised Formulas


Serosep's personnel include qualified chemists that monitor the production of biopsy fixatives from start to finish.
Quality Control of our raw materials, manufacturing process and final testing ensures Serosep fixatives provide consistent fixation from batch to batch.


Serosep guarantees our customers peace of mind by being able to offer each batch of product with a quality control certificate. Serosep fixatives carry the CE ivd mark.